Top 10 Polyvinyl Pyrrolidone Manufacturers Worldwide

Table of contents

1. Hangzhou Rainbow Import & Export Co., Ltd.
2. BASF
3. Ashland
4. Boai NKY Pharmaceuticals
5. Shanghai Aladdin Biochemical Technology
6. Showa Denko, Japan
7. IOL Chemicals, India
8. Hubei Svitu New Materials
9. Ulanqab Kema New Materials
10. Merck KGaA, Germany

1. Hangzhou Rainbow Import & Export Co., Ltd.

In 1992, the company's predecessor, Zhejiang Sunflower New Materials Co., Ltd., was established, specializing in PVP production. Mr. Wu Jiaxiang, the chief expert of the national PVP research and development project, served as the general manager. In 2002, the company was restructured into a private enterprise and Hangzhou Sunflower Technology Development Co., Ltd. (STD) was established to continue to develop and produce PVP series of technical and cosmetic products. The company has a GMP production line with an annual output of 600 tons of low molecular weight povidone (povidone K12, K15, K17, K25, K30), 800 tons of high molecular weight povidone (povidone K60, K90, K120), 300 tons of high stability povidone iodine, and 100 tons of sodium chondroitin sulfate.

Hangzhou Rainbow Import & Export Co., Ltd mainly produces chemical products, such as povidone, cross-linked povidone, povidone iodine, chondroitin sulfate, etc. The following are the characteristics of these products:

1. Povidone: It is a linear 1-vinyl-2-pyrrolidone synthetic polymer that can absorb toxins. It is usually made into injections and used for certain poisoning diseases.

2. Cross-linked povidone: It is a water-insoluble synthetic cross-linked N-vinyl-2-pyrrolidone homopolymer. It is a white or off-white powder, almost odorless, and hygroscopic. It is insoluble in water, ethanol, chloroform or ether. It has a high capillary/water content, a large specific surface area, extremely strong hydration ability, high and rapid water absorption, strong water absorption and expansion ability, and a swelling coefficient of 2.25-2.30. It also has the same complexing ability as polyvinyl pyrrolidone and can complex a variety of substances. It is often used as a water-insoluble tablet disintegrant, dry adhesive, filler and excipient, etc. It can also be used as a dissolution promoter.

3. Povidone iodine: There are many dosage forms. The solution can be used for skin fungal infections, suppurative dermatitis, small-area mild burns and scalds, and small-area skin and mucosal wounds. The suppository is used for candidal vulvovaginal disease, bacterial vaginosis, mixed infection vaginitis, and hemorrhoids; gels, creams, and vaginal effervescent tablets are used for candidal vulvovaginal disease, bacterial vaginosis, and mixed infection vaginitis; the film is used to treat candidal vaginitis; the gargle is used for oral diseases such as stomatitis, oral ulcers, pharyngitis, pericoronitis, and periodontitis. It can also be used for disinfection before oral surgery and daily oral disinfection and health care.

4. Chondroitin sulfate: There are oral preparations, injections, and eye drops. Oral preparations can lower blood lipids, treat hyperlipidemia, prevent and treat various cardiovascular diseases, treat various pains, promote healing of traumatic wounds, assist in the treatment of diseases such as nephritis and chronic hepatitis, and also have anti-tumor effects; injections are mainly used for the auxiliary treatment of atherosclerotic diseases, neuralgia, neuralgia, and joint pain; eye drops have the effect of promoting corneal wound healing, exudate absorption and eliminating inflammation, and are used for diseases such as keratitis, corneal injury, and corneal ulcers.

Insoluble Polyvinylpyrrolidone

Insoluble Polyvinylpyrrolidone, also commonly

PVP/povidone K

PVP/povidone K, A polyvinyl polymer of

PVP/VA Series 25086-89-9 Properties and Differentiation A...

PVP/VA (SUNLYDONE® VA Series)

(PVP) K Series 9003-39-8

Polyvinylpyrrolidone

(SUNLYDONE® K Series)

PVP Iodine Pharmaceutical Raw Materials USP

PVP-I,pvpi, PVP Iodine manufacturer / supplier

Tablet Binder Copovidone CAS 25086-89-9

Medical Material, CAS 25086-89-9, Vinyl

Povidone Iodione Solution 25655-41-8 50KG or 200KG/drum

Povidone-Iodine solution (SUNVIDONE ® PIs)

Glue Stick Adhesive PVP K90 Solution

Glue stick adhesive CONTENTS: PVP, water

1. Customer first: As an import and export enterprise, we will focus on meeting customer needs, and be committed to providing high-quality commodity procurement and import and export services for domestic and foreign customers, striving to meet customer requirements in terms of product variety, quality, price, delivery time, etc., and take customer satisfaction as an important criterion for measuring service quality.

2. Integrity management: In business activities, we uphold the principle of integrity, truthfully provide customers with information on products, service content and prices, do not defraud or conceal, strictly fulfill contractual agreements, ensure fairness, justice and transparency of transactions, and establish long-term and stable cooperative relationships with customers.

3. Professional and efficient: The company's team members have professional import and export business knowledge and rich industry experience, can provide customers with professional consulting and solutions, efficiently handle orders, customs declarations, logistics and other links, reduce customers' time costs and energy consumption, and ensure that goods can be imported and exported quickly and smoothly.

4. Innovation and enterprising: Pay attention to market dynamics and industry development trends, continuously innovate service models and business content, actively explore new markets and business opportunities, provide customers with more diversified product and service options, drive corporate development with innovation, and create greater value for customers.

5. Win-win cooperation: We attach importance to the cooperative relationship with suppliers, customers, logistics partners and other parties. By establishing a good cooperation mechanism, we can achieve resource sharing, complementary advantages, jointly explore the market, maximize the interests of all parties in the cooperation, and promote the coordinated development of the industry.

2. BASF
Headquarters: Ludwigshafen, Germany
Background: As the world's largest chemical company, BASF has been producing PVP since the 1960s and has full industry chain technology from NVP monomers to cross-linked polymers. Its German headquarters plant uses a continuous flow reactor process with an annual production capacity of 12,000 tons.
Technical highlights: Developed low endotoxin control technology (<0.05 EU/g) for medical-grade PVP-K30, meeting the standards for injection excipients.
Disadvantages: Energy costs of European factories account for as much as 28%, and coupled with the pressure of carbon tariffs, it has announced that part of the production capacity will be transferred to Malaysia in 2024.

3. Ashland
Headquarters: Delaware, USA
Background: Ashland entered the market by acquiring ISP's PVP business, focusing on high value-added products such as PVP/VA copolymers, accounting for 35% of the global PVP share for hair dyes.
Technical highlights: Patented cross-linking technology (US20220169982A1) increases the swelling rate of PVPP to 8.5 mL/g, significantly better than the industry average of 7.2 mL/g.
Disadvantages: Dependent on the supply of NVP monomers from the petroleum route, the delivery cycle will be extended to 90 days in 2023 due to raw material shortages.

4. Boai NKY Pharmaceuticals
Headquarters: Jiaozuo City, Henan Province, China
Background: The largest PVP producer in China, with a production capacity of 25,000 tons in 2024, accounting for 18% of the global market. Its Jiaozuo base uses the acetylene method to synthesize NVP, which is 12% cheaper than the petroleum route.
Technical highlights: Developed food-grade PVP-K90 (K value 88-96) for red wine clarification, and passed the FDA's GRAS certification.
Disadvantages: Insufficient wastewater treatment capacity, net profit fell 27% in 2023 due to environmental protection fines.

5. Shanghai Aladdin Biochemical Technology
Headquarters: Shanghai, China
Background: A company listed on the Science and Technology Innovation Board (688179), with scientific research reagents as the core, the PVP product line covers the full range of K12-K120, and has more than 75,000 chemicals in stock.
Technical highlights: Launched pre-sterilized PVP solution (RNase-free) to meet the needs of biological laboratories, with a market share of 41% of the domestic scientific research market in 2024.
Disadvantages: The industrial-grade PVP production capacity is only 3,000 tons/year, which is difficult to compete with professional chemical companies.

6. Showa Denko, Japan
Headquarters: Tokyo, Japan
Background: Focusing on the field of electronic chemicals, its PVP products are used as dispersants for semiconductor photoresists with a purity of 99.99%.
Technical highlights: Nano-grade PVP powder (particle size <100 nm) can improve the uniformity of OLED films and has won orders from Samsung Display.
Disadvantages: The production cost is extremely high, and the price of electronic-grade PVP is 6-8 times that of ordinary industrial products.

7. IOL Chemicals, India
Headquarters: Punjab, India
Background: Relying on cheap labor and loose environmental protection supervision, it has rapidly expanded to a production capacity of 10,000 tons/year, focusing on the African and Southeast Asian markets.
Technical highlights: Developing a low-cost spray drying process to reduce the production cost of PVP-K30 to US$1,200/ton.
Disadvantages: It will be restricted by the EU REACH regulations in 2024 because the residual γ-butyrolactone in the product exceeds the standard (>50 ppm).

8. Hubei Svitu New Materials
Headquarters: Wuhan, Hubei, China
Background: Founded in 2020, it focuses on PVP for new energy battery binders. In 2024, the installed capacity will account for 13% of the domestic power battery market.
Technical highlights: The modified PVP-SH series (thiol functional group) improves the cycle stability of silicon-carbon negative electrodes to more than 500 times.
Disadvantages: The patent layout is weak, and the core process is suspected of imitating South Korea's LG Chemical technology.

9. Ulanqab Kema New Materials
Headquarters: Inner Mongolia Autonomous Region, China
Background: Relying on local calcium carbide resources, it builds an integrated production line of "NVP-PVP-PVPP", and its production capacity will exceed 8,000 tons in 2024.
Technical highlights: Using wind power green electricity production, the carbon footprint is 42% lower than the industry average.
Disadvantages: The remote location leads to an increase of 18% in logistics costs, and the low temperature in winter affects the efficiency of polymerization reactions.

10. Merck KGaA
Headquarters: Darmstadt, Germany
Background: A major global supplier of pharmaceutical-grade PVP, its products comply with EP, USP and JP pharmacopoeia standards and are used in more than 50% of marketed injectables.
Technical highlights: Ultrafiltration purification technology reduces heavy metal residues to <1 ppb, meeting the needs of cell therapy products.
Disadvantages: The production line certification cycle is as long as 24 months, making it difficult to quickly respond to emerging market needs.

Polyvinyl pyrrolidone (PPP) has important applications in many fields. It is a high molecular weight polymer with excellent properties and is often used in the pharmaceutical industry as a binder for drug preparations. In some special scenarios, such as when used with surfactants (SDS), it can play a unique role. In materials science, the adsorption behavior of PPP on oxidized surfaces and its interaction as a capping agent are the focus of researchers. Although PPPs of different molecular weights have different properties, PPPs of a specific molecular weight such as 100,000 g/mol also have potential application value.

Q: What is the main role of polyvinyl pyrrolidone in medicine?

A: In medicine, polyvinyl pyrrolidone can be used as a binder for tablets to help drug molding; it can also be used as a solubilizer to increase the solubility of some poorly soluble drugs.

Q: What are the advantages of using polyvinyl pyrrolidone with SDS?

A: The combination of the two can improve the dispersibility and stability of the system. For example, in cosmetics or certain chemical products, it can make the ingredients better mixed.

Q: What effect does a specific molecular weight of polyvinyl pyrrolidone have on performance?

A: Polyvinyl pyrrolidone with different molecular weights will have different properties such as viscosity, solubility, and film-forming properties. For example, polyvinyl pyrrolidone with a molecular weight of 100,000 g/mol has a large relative molecular weight and may form a tougher film.