PVP/povidone K

PVP or povidone is a hygroscopic, amorphous, synthetic polymer consisting of linear 1-vinyl-2-pyrrolidinone groups. As a binder, PVP is used in the concentration range of 0.5%–5% w/w. Different degrees of polymerization of PVP resulted in polymers of various molecular weights. It is generally characterized by its viscosity in aqueous solution relative to that of water and expressed as a K value in the range of 10–120.

Povidones with K-values ≤ 30 are manufactured by spray drying as spheres, whereas povidones with higher K-values are manufactured by drum drying as plates. Wet granulation with povidone K25/30/90 generally gives harder granules with better flow properties than with other binders with lower friability and higher binding strength. Moreover, povidone also promotes the dissolution of APIs. For example, the drug release was faster in paracetamol tablets with 4% povidone K90 compared to tablets with gelatin or hydroxypropyl methylcellulose (HPMC) as binder.

That PVP was more efficient than HPMC owing to the lower work of cohesion and adhesion of HPMC. It could be further attributed to the better adhesion of PVP, especially to hydrophilic surfaces. Using PVP solution as granulating agent, it was observed that the addition of MCC as an insoluble excipient to a lactose-based formulation led to increase in solvent requirement and produced larger granules.

• As a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process;
• As an emulsifier and disintegrant for solution polymerization;
• To increase resolution in photoresists for cathode ray tubes (CRT);
• In aqueous metal quenching;
• For production of membranes, such as dialysis and water purification filters;
• As a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating;
• As a thickening agent in tooth whitening gels;
• As an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation;
• As an additive to Doro's RNA extraction buffer [citation needed];
• As a liquid-phase dispersion enhancing agent in DOSY NMR;
• As a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly;
• As a stabilizing agent in all inorganic solar cells. 

Use exactly as directed on the label, or as prescribed by your doctor.

Povidone iodine topical is available in many different forms, such as a liquid, ointment, aerosol powder, cream, spray, swab, and soap. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Always follow directions on the medicine label about using this medicine on a child. Some forms of povidone iodine topical should not be used in children of certain ages.

Povidone iodine topical is usually applied to the skin as needed. First clean the area to be treated.

Shake povidone iodine topical spray well just before each use.

Allow the medicine to dry completely on the skin before applying a bandage. Do not apply a tight bandage.

Do not use this medicine on deep wounds, puncture wounds, animal bites, or serious burns. Do not apply over large skin areas.

When treating an infection, you may be given antibiotic medication to take by mouth. Use all medicines for the full prescribed length of time, even if your symptoms quickly improve.

Povidone iodine topical used in the mouth may be used up to 4 times per day. How often you can use this medicine depends on what form you use. Follow all directions on the medicine label. 

The company has the GMP production lines of 600 tons annually of Povidone at low molecular weight ( Povidone K12, K15, K17, K25 and K30), 800 tons annually of Povidone at high molecular weight ( Povidone K60, K90, K120), 300 tons annually of Povidone Iodinated with high stability and 100tons annually of Chondroitine Sulfated Sodium. The company also first finished the industrial cultivation of artificial cultivating of Cordyceps and the concerned products are under marketing now. HSP will take pharmaceutical biological products or biological extracts with advantage of techniques or resources as the new development direction