Hangzhou Rainbow Import & Export Co., Ltd. is one of the leading manufacturers and suppliers of pvp/va 64 copolymer/copovidonee in China. With abundant experience, we warmly welcome you to buy customized pvp/va 64 copolymer/copovidonee from our factory. If you have any enquiry about free sample, please feel free to email us.

Huzhou Sunflower Pharmaceutical Co. Ltd : Your Trustworthy PVP/VA 64 Copolymer/Copovidone Supplier!

Huzhou Sunflower Pharmaceutical Co. Ltd. focus on the development and producing of pharmaceutical excipients and API's. Led by Mr. Wu Jiaxiang, the main PVP founder in China, the team possessed tens of concerned process and application techniques, gathered 35 years of experience of sustainable R&D, engineering practice and marketing, specially in Polyvinylpyrrolidone series (Povidone, Crosspovidone, Copovidone and Povidone iodinated), Chondroitine Sulfate Sodium series and artificial cultivating of Cordyceps. The company is well known as full range covering, high quality and good service in the industry. The company is widely praised by the customer both at home and abroad.

Our Advantages

Products Widely Used

Our company produces NVP Homopolymer, NVP Copolymer, NVP Crosslinked Polymer, PVP Complex Compound and so on, which are widely used in the field of industry, pharmaceutical, cosmetics.

Strong Production Capability

Our company has the GMP production lines of 600 tons annually of Povidone at low molecular weight ( Povidone K12, K15, K17, K25 and K30), 800 tons annually of Povidone at high molecular weight ( Povidone K60, K90, K120), 300 tons annually of Povidone Iodinated with high stability and 100tons annually of Chondroitine Sulfated Sodium.

Quality Guaranteed

Our company has passed ISO quality certification system. Our company has obtained certificates such as ISO9001:2008, MF032698. All products are strictly tested in accordance with industry standards and contract agreements before leaving the factory.

Rich Products

Our company has rich products, such as Polyvinylpyrrolidone series (Povidone, Crosspovidone, Copovidone and Povidone iodinated), Chondroitine Sulfate Sodium series and artificial cultivating of Cordyceps.

Tablet Binder Copovidone CAS 25086-89-9

Tablet Binder Copovidone CAS 25086-89-9 is medical Material. The Copovidone is a water-soluble organic polymer, and is a linear copolymer of vinyl N- (NVP) and vinyl acetate (VA). Since the structure of and NVP is the structure of and VA, it has the properties of both PVP and PVAC. Compared the nature of the above three products, polyvidone retained the good PVP water solubility, adhesion and membrane, and than the PVP is relatively much lower water absorption and more broad solubility, better plasticity and stronger surface activity.

Vinylpyrrolidone/Vinyl Acetate Copolymer Solution And Powder

Ethylene-vinyl acetate (EVA), also known as poly(ethylene-vinyl acetate) (PEVA), is a copolymer of ethylene and vinyl acetate. The weight percent of vinyl acetate usually varies from 10 to 50%, with the remainder being ethylene. There are three different types of EVA copolymer, which differ in the vinyl acetate (VA) content and the way the materials are used.

PVP/VA Series 25086-89-9 Properties And Differentiation Are Determined By The VP/VA Ratio In The Polymer

VA Series acts as a film forming agent. It is produced by the free-radical polymerization of monomers in the ratio of 50/50 (VP/VA). Shows good propellant compatibility. It forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal. PVP/VA series find application in formulating hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers. It offers strong & stiff hold, enhanced high humidity curl retention.

Copovidone Pharmaceutical Excipients With Many Uses

Copovidone Pharmaceutical Excipients are White or slightly yellowish, free-flowing powder with a faint characteristic odor and practically no taste.They dissolve in all hydrophilic solvents. Solutions of more than 10% concentration can be prepared in: water; ethanol; isopropanol; methylene chloride; glycerol; propylene glycol; It is less soluble in: ether; cyclic, aliphatic and alicyclic hydrocarbons.

PVP/VA 64 Copolymer/Copovidone

PVP/VA 64 Copolymer/Copovidone Specifications CAS No.: 25086-89-9 Type: soluble binder for granulation. dry-binder. film-forming agent Grade Standard: Cosmetic Grade, Medicine Grade, Tech Grade Place of Origin: Zhejiang, China (Mainland) Brand Name:STD Type: Auxiliaries and Other Medicinal...

PVP/VA 64 Copolymer/Copovidone

25086-89-9

Medical Material, CAS 25086-89-9, Vinyl Acetate manufacturer / supplier in China, offering Tablet Binder Copovidone CAS 25086-89-9, Local Anesthetic Drug Reduce Pain Dentistry CAS 51-05-8 Procaine HCl, 99% Purity Active Pharmaceutical Ingredients CAS 78246-49-8 Paroxetine Hydrochloride and so on.

CAS 25086-89-9

PVP/VA 64 Copolymer/Copovidone

Introduction to PVP/VA 64 Copolymer/Copovidone

The VA 64 Copolymer/Copovidone, an analog of povidone, is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, Copovidonee can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier. Copovidone has better plasticity than povidone as a tablet binder, is less hygroscopic, more elastic, and better for film-forming applications than povidone. Copovidone is also used in cosmetics as a thickener, dispersant, lubricant, film-forming agent and binder. It is widely used in the food, cosmetic and pharmaceutical industry.

Advantages of PVP/VA 64 Copolymer/Copovidone

High Solubility

Copovidone is a commonly used hydrophilic polymer of well-established functionality for stabilizing amorphous solid dispersions with various poorly soluble drugs, e.g. indomethacin, meloxicam, itraconazole, or olanzapine. High solubility in water, lower risk of interactions in comparison to polyvinyl pyrrolidone and a high glass transition temperature (Tg = 106 °C) are important features of this polymer.

Less Hygroscopic

Hygroscopy is the phenomenon of attracting and holding water molecules via either absorption or adsorption from the surrounding environment, which is usually at normal or room temperature. The presence of vinyl acetate group in Copovidonee structure makes it less hygroscopic than other polymers, consisting of 1-vinyl-2-pyrrolidinone groups.

Activity Against Biofilms

The in vitro efficacy of PVP against S. epidermidis and S. aureus growth, as well as the inhibition of staphylococcal biofilm formation at sub-inhibitory concentrations exist. Furthermore, in a CDC-reactor model, PVP was efficacious in the presence of biofilms grown in a mixed culture comprising MRSA and C. albicans, even at highly diluted concentrations.

Low Toxicity

PVP has very low cytotoxicity compared to other antiseptics when tested on skin (vs. PHMB, octenidine, chlorhexidine and hydrogen peroxide) and oromucosal (same as octenidine but superior to chlorhexidine) cell lines.

How to use PVP Drops

Follow All Directions On The Product Package
If your doctor has prescribed this medication, use this medication in the affected eye(s) as directed by your doctor. If you have any questions, ask your doctor or pharmacist.

Do Not Use a Solution That Has Changed Color Or Is Cloudy
Certain products (containing glycerin with polysorbates, among other ingredients) may have a milky appearance. This is okay as long as the solution does not change color. Some eye drops need to be shaken before use. Check the label to see if you should shake your product before using.

To Apply Eye Ointment/Drops/Gels
Wash hands first. To avoid contamination, do not touch the dropper tip or the tube tip of the ointment or let it touch your eye or any other surface. Always replace the cap tightly after each use. Tilt your head back, look up, and pull down the lower eyelid to make a pouch.

For drops/gels, place the dropper directly over the eye and squeeze out 1 or 2 drops as needed. Look down and gently close your eye for 1 or 2 minutes. Place one finger at the corner of the eye near the nose and apply gentle pressure. This will prevent the medication from draining away from the eye.

For an ointment, hold the tube directly over the eye and gently squeeze a small strip (one-fourth of an inch or roughly 6 millimeters) of ointment into the pouch. Release the eyelid, close the eye, and slowly roll your eye in all directions to spread the medication. Blot away any extra ointment from around the eye with a clean tissue.

Wait At Least 5 Minutes Before Applying Other Medications
If you are also using another kind of eye medication (such as drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Application of PVP/VA 64 Copolymer/Copovidone

Applications in Pharmaceutical Formulations or Technology
Copovidone was developed as an improvement over Povidone (binder). Its favourable technical properties, namely better flowability, lower hygroscopicity, spherical particle shape, plasticity, lower glass-transition temperature, and hydrophobic–hydrophilic balance, rendered Copovidone highly advantageous in direct compression and roller-compaction tabletting operations. While Copovidone is still used as a dry binder (for direct compression and roller compression), its main utility is as a matrix former for the development of solid dispersions, film former (especially in the formulation of moisture-barrier coatings), and as a matrice former for sustained-release solid dosage forms.

1). Binder in Tablets
Copovidone performs superbly as a dry binder for direct compression applications. It is particularly preferred for formulations susceptible to capping due to its plasticity. Finer grades have demonstrated superior binding performance compared with either Povidone and Cellulose-based polymers. Formulations developed with Copovidone show a direct relationship between tablet hardness, friability, porosity and disintegration with the applied compaction force.

2). Binder in Wet Granulation
The high solubility of Copovidone in water and standard granulation liquids makes it as an ideal binder in wet granulation operations. It may be added either as a solution or in the form of a dry powder followed by the addition of the granulating solvent or a combination of both. Copovidone, owing to its low hygroscopicity, allows greater predictable granulation endpoints and its granules have a much less propensity to stick to tooling, even when conducted under less favourable conditions.

3). Roller Compression
Copovidone has been shown to be particularly well-suited for use in roller compaction. It is an excipient of choice when particle size distribution and particle shape considerations are critical during roller compression process design. Owing to its spherical shape and fine size Copovidone gives better surface coverage and develops multiple bridges that lead to hard tablets with a reduced friability.

4). Film-Coating Film Former
Copovidone is a film former and it soluble membranes whose solubility is independent of pH. Copovidone films are also less hygroscopic, but more flexible compared with those formed by Povidone. For best results, it's used in combination with other film-forming polymers that are less hygroscopic. Due to its flexibility, a plasticizer is not required.

5). Polymer for Amorphous Solid Dispersions
Copovidone is a suitable polymer for developing amorphous solid dispersions that are both kinetically and thermodynamically stable. Both spray-drying and hot melt extrusion approaches can be reliably used.

6). Other Uses
● Inhibition of crystallisation of APIs in liquid soft-gel formulations
● Sugar coating applications (to improve adhesion)
● Subcoating of tablets (film coating)

How to Dissolve PVP/VA 64 Copolymer/Copovidone

PVP is relatively simple to dissolve, usually by adding powder while stirring. Don't stir too fast to prevent powder from splashing, because PVP powder is relatively light, that is, it is more friable. It can be dissolved directly at room temperature. If heated, it will dissolve faster.

Take PVP K30 as an example, it can usually be prepared into a 30% aqueous solution (30 grams of K30 powder, water is 70 grams). It can be prepared at a higher concentration, but the viscosity of the system will become larger and larger, and the dissolution time will become longer.

PVP K30, after being prepared into a 30% aqueous solution, the color of the aqueous solution will change from nearly colorless to light yellow, which is related to the purity and grade of PVP.

If 1 gram of PVP is dissolved in 100 ml of water, this is a low-concentration PVP solution, that is, a dilute solution. Even PVP with a high K value, such as PVP K120 and PVP K150, will also dissolve very well.

PVP has a characteristic when it dissolves. If it is not completely broken up during stirring and forms a mass, the outer layer will be wetted by the water when it comes into contact with water, while the inside is still in a dry powder state. This will require a longer dissolution time. If it hasn't dissolved after a day, just keep stirring and it will completely dissolve.

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Ultimate FAQ Guide to PVP/VA 64 Copolymer/Copovidone

Q: What is the difference between crospovidone and Copovidonee?

A: Typically, Copovidonee is used as dry binder and crospovidone as disintegrant in tableting formulations. The use of dry binder and disintegrant needs to be balanced to assure both: strong but quickly disintegrating tablets.

Q: What are the benefits of Copovidone?

A: It provides erodible instant release matrix.
It is a solubilizer, dispersant, crystallization inhibitor and matrix former.
For direct compression, roller compaction and wet granulation, suitable for markets with higher humidity exposure.
It has excellent stability throughout the extrusion process.
A coarse powder provides a dust free handling, good flowability and faster extruder feeding.

Q: How to Store Copovidonee?

A: Copovidone is stable and should be stored in a well-closed container in a cool, dry place. The standard shelf life is given as 24 months. However, when Copovidone is exposed to high moisture levels, its stability may be reduced. Correct storage of the raw material is therefore highly advised.

Q: What is the function of the excipient Copovidonee?

A: Well-known in the industry as a multipurpose excipient, Copovidonee functions as a binder, solubilizer/solid dispersion carrier and film former in a variety of pharmaceutical formulations.

Q: What is the most common use of Copovidonee?

A: Copovidone is a water-soluble synthetic homopolymer with gentle adhesive properties. It is available in a broad range of molecular weights, from 8 to 1300 kDa. It does not form micelles or particulate structures in standard formulations. Usually, viscosity of solution determines the maximum concentration used. The most common use is as a tablet binder and tablet-coating additive; however, it is also used in formulations of antibiotics, chemotherapeutic drugs, and ophthalmic and topical solutions.

Q: How does PVP work?

A: PVP contains povidone, a polymer (substance made up of large molecules). When you apply this medication into your eyes, povidone forms a coat over your eyes. This helps to protect and moisten your eyes to relieve dryness and irritation.

Q: What are the side effects of PVP?

A: Common Side Effects:
Some burning or stinging in the eye
Feeling as if there's something in the eye
Blurry vision
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Q: What are applications of PVP?

A: Mainly used in solid dosage forms as a granulation aid and as a dry binder in tablets, capsules and granules. Also as a matrix-forming polymer in sustained-release tablets.
Film-forming polymer in tablet coatings.
Topically as a film former in sprays.

Q: Why does polyvinyl pyrrolidone have good solubility?

A: PVP is a polar polymer molecular structure. It contains both hydroxyl groups and pyrrole and vinyl groups. It is an amphoteric molecule like PEG and PPG. It is soluble in water and non-polar solvents such as ethyl acetate, MIBK and carbon tetrachloride. Therefore, in addition to being a resin, it is also a good amphoteric non-ionic surfactant component.

Q: What is the appropriate amount of PVP in cosmetics?

A: The recommended amount of PVP in cosmetics is 0.5-5%. Specifically, PVP is widely used in daily cosmetics due to its good dispersibility and film-forming properties. It can be used to make styling lotions, hair sprays and mousses, and as a sunscreen in hair care products. In addition, PVP is also used in shampoos to enhance foam stability, and as a dispersant and affinity agent in wave styling and hair dyes.

Q: What are the functions of PVP in cosmetics?

A: PVP has multiple functions in cosmetics, mainly stabilizing dispersions such as emulsions and suspensions (colloid protection) and increasing viscosity, film-forming in hair care styling products, gelling in gel products, lubricating, moisturizing and film-forming in skin care products (masks), stabilizing foam in foam products, and as a pigment stabilizer, deodorant, fragrance retainer, mild agent (reducing the irritation of certain components to the skin) in various cosmetic formulas.

Q: Why PVP has the function of being a pharmaceutical excipient?

A: PVP has good adhesion and strong solubility. After being taken, the tablets formed by PVP first dissolve rapidly in the digestive tract, causing the tablets to swell locally and disintegrate, releasing drug fragments, which in turn accelerates the dissolution and absorption of the drug, playing a role in quickly exerting the drug's efficacy. PVP is soluble in water and most organic solvents. For these reasons, PVP has been widely used in pharmaceutical tablets.

Q: What is the use of PVP as a pharmaceutical excipient?

A: The important use of PVP as a pharmaceutical excipient is as a coprecipitant. The main reason why PVP is used as a pharmaceutical coprecipitant is that the carbonyl group in the PVP molecule can be combined with the active hydrogen in the insoluble drug molecule. On the one hand, the relatively small drug molecule becomes an amorphous state and enters the PVP macromolecule. On the other hand, the hydrogen bond does not change the property of PVP being easily soluble in water. As a result, the insoluble drug molecules are dispersed in the PVP macromolecule through hydrogen bonds, making it easy to dissolve.

Q: How PVP is used as a drug film coat?

A: It is used as a drug film coat, drug capsule shell and controlled release membrane. The drug film coat and capsule shell made of PVP are not easy to break in a dry environment. The appropriate amount of PVP is used together with other insoluble polymers to make permeable membranes of different thicknesses and pore sizes, which can adjust the rate at which the drug passes through the membrane, thereby achieving the effect of controlled release of the drug effect.

Q: Does PVP have the effect of prolonging drug efficacy?

A: Using the precipitant effect between PVP molecules and drug molecules can play a role in prolonging the release of drugs, which is the opposite of the solubilization and rapid effect. Controlling the degree of association between PVP molecules and drug molecules can make the drug molecules slowly released in the human body after association, slowing down their dissolution rate and prolonging the drug efficacy. PVP has the effect of prolonging the efficacy of drugs such as penicillin, chloramphenicol, insulin, sodium salicylate, procaine, and cortisone.

Q: What role does PVP play in injections and eye drops?

A: PVP plays an important role in injections and eye drops. For example, PVP is used in some injections. Due to the complexation between it and the drug, it plays a role in solubilization on the one hand. On the other hand, for some drugs that will crystallize or precipitate if left for too long, PVP can play a role in dispersion and stability. PVP can be used in eye drops to reduce irritation to the eyes and prolong the duration of action of eye drops.

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PVP/VA 64 Copolymer/Copovidonee

Our Advantages

Advantages of PVP/VA 64 Copolymer/Copovidone

Application of PVP/VA 64 Copolymer/Copovidone

How to Dissolve PVP/VA 64 Copolymer/Copovidone

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Ultimate FAQ Guide to PVP/VA 64 Copolymer/Copovidone