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Chemical Name:Vinylpyrrolidone/Vinylacetate copolymers
USP/EP Name:Copovidone
INC/CTFA Name:VP/VA COPOLYMER
Molecular Formula:(C₆H₉NO)n+(C₄H₆NO2)m

Appearance: White Powder
CAS N0.25086-89-9
VAisa vinylpyrolidone-vinyl acetate copolymer that is soluble both in water and inalcohols.
It is used in the pharmaceutical industry as binders,granulating agents,retarding agents and film forming agents in drugs.

Characteristic

White or slightly yellowish, non-flowing powder, with a weak characteristic odor and almost no taste.
Soluble in all hydrophilic solvents. Solutions with concentrations exceeding 10% can be prepared in water, ethanol, isopropanol, dichloromethane, glycerol, propylene glycol, and less soluble in ethers, cycloaliphatic and alicyclic hydrocarbons.

This product is an excellent tablet adhesive with the characteristics of high hardness and low brittleness, and can be used in humid environments.

Specification

Appearance of solution(10%)	BY₅,B₅min.	Impurity C	10ppm max.
K value	25.2-30.8	Heavy metals	20ppm max
Aldehydes	500ppm max.	Loss on drying	5.0%max
Peroxides	400ppm max.	sulphated ash	0.1%max
Hydrazine	lppm max.	Ethenyl acetate	35.3%-42.0%
Impurity A	0.5%max.	Nitrogen	7.0%-8.0%
I mpurity B	10ppm max.

Application

Pharmaceutical Industry: In the pharmaceutical industry, polyvinyl pyrrolidone is widely used in the preparation of tablets, especially in the preparation of composite tablets, which can effectively improve the uniformity and stability of tablets.

Nutritional Supplements: In the production of nutritional supplements, it is also often used as a binder to improve the quality and taste of the finished product.

Food Industry: It is also used in some food applications as a thickener or stabilizer to improve the texture and stability of food.

FAQ

1.How to choose the right Copovidone?
Its molecular weight, viscosity and compatibility should be considered according to the specific formulation requirements, such as drug properties, tablet type and production process.

2. What are the precautions for the use of Copovidone?
Attention should be paid to its dosage compatibility with other excipients to ensure compliance with relevant regulations and standards to ensure the quality and safety of the final product.

3. Is Copovidone safe for the human body?
It is considered safe within the prescribed dosage range and has good biocompatibility, but it still needs to follow the safety standards of drugs.

4. How to store Copovidone?
It should be stored in a cool and dry place, avoiding moisture and high temperature to maintain its performance and shelf life.

5. How to test the performance of Copovidone?
Performance can be evaluated through various laboratory tests, including viscosity test, solubility test and mechanical strength test.

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