Hangzhou Rainbow Import & Export Co., Ltd. is one of the leading manufacturers and suppliers of tablet binder copovidonee cas 25086-89-9 in China. With abundant experience, we warmly welcome you to buy customized tablet binder copovidonee cas 25086-89-9 from our factory. If you have any enquiry about free sample, please feel free to email us.

What is Tablet Binder Copovidone CAS 25086-89-9 ?

Tablet Binder Copovidone CAS 25086-89-9, is a synthetic polymer used in a variety of applications, including pharmaceuticals, cosmetics, and food processing. This polymer is composed of a hydrophilic backbone, which is a combination of polyvinylpyrrolidone (PVP) and a hydrophobic side chain, which is vinyl acetate. The combination of these two components gives this compound its unique properties, such as its ability to form stable emulsions and suspensions, as well as its solubility in both aqueous and non-aqueous systems. This makes it an ideal choice for a variety of applications, such as drug delivery systems, emulsions, and suspensions.

Why Choose Us?

Rich Experience

1992, Zhejiang Sunflower New Material Co.,Ltd. which was predecessor of STD, engaged in PVP, was set up and Mr. Wu Jiaxiang, the chief expert of the state's R&D project for PVP in China, was appointed as the general manager.

Advanced Equipment

2004, Zhejiang MY Sunflower Pharmaceutical Co.,Ltd. which is JV of STD was established for production of PVP in Pharm.Grade. GMP workshops were founded for POVIDONE, POVIDONE IODINE and POVIDONE IODINE SOLUTION.

Reliable Product Quality

2010, SPP expand the factory from 4000M2 to 12,000M2. After that the capacity of 3500tons of powder and 5000tons of liquid products annually till the end of 2011.

Professional Technical Team

Led by Mr. Wu Jiaxiang, the main PVP founder in China, the team possessed tens of concerned process and application techniques, gathered 35 years of experience of sustainable R&D, engineering practice and marketing, specially in Polyvinylpyrrolidone series (Povidone, Crosspovidone, Copovidone and Povidone iodinated), Chondroitine Sulfate Sodium series and artificial cultivating of Cordyceps.

PVP/VA 64 Copolymer/Copovidone

PVP/VA 64 Copolymer/Copovidone Specifications CAS No.: 25086-89-9 Type: soluble binder for granulation. dry-binder. film-forming agent Grade Standard: Cosmetic Grade, Medicine Grade, Tech Grade Place of Origin: Zhejiang, China (Mainland) Brand Name:STD Type: Auxiliaries and Other Medicinal...

25086-89-9

Medical Material, CAS 25086-89-9, Vinyl Acetate manufacturer / supplier in China, offering Tablet Binder Copovidone CAS 25086-89-9, Local Anesthetic Drug Reduce Pain Dentistry CAS 51-05-8 Procaine HCl, 99% Purity Active Pharmaceutical Ingredients CAS 78246-49-8 Paroxetine Hydrochloride and so on.

CAS 25086-89-9

Vinylpyrrolidone/vinyl Acetate Copolymer Solution and Powder

Vinylpyrrolidone/vinyl acetate copolymer solution and powder Specifications CAS No.: [25086-89-9] Place of Origin: Zhejiang, China (Mainland) Brand Name:STD Trade Name: Sunlydone VA Description: Copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) Appearance:White or creamy...

PVP/VA Series 25086-89-9 Properties and Differentiation Are Determined by the VP/VA Ratio in the Polymer

PVP/VA (SUNLYDONE® VA Series) SUNLYDONE® VA Series Vinylpyrrolidone/Vinylacetate copolymers (C 6 H 9 NO) N (C 4 H 6 NO 2 ) M Mw=(111.1) N +(86.1) M INCI/CTFA: VP/VA Copolymer CAS No.: [25086-89-9] Trade Name: Sunlydone VA Description: Copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA)...

Copovidone Pharmaceutical Excipients with Many Uses

SUNVIDONE ® VA Synonyms: Copovidone;Copolyvidone; PVP/ VAc CTFA/INCI:VP/VA copolymer CAS No.: [25086-89-9] Trade Name: Sunvidone ® VA SUNVIDONE ® VA is a vinylpyrrolidone-vinyl acetate copolymer that is soluble both in water and in alcohols. It is used in the pharmaceutical industry as binders,...

PVP/VA 64 Copolymer/Copovidone

Tablet Binder Copovidone CAS 25086-89-9

Benefits of Tablet Binder Copovidone CAS 25086-89-9

Copovidone, an analog of povidone, is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, Copovidonee can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.

Copovidone has better plasticity than povidone as a tablet binder, is less hygroscopic, more elastic, and better for film-forming applications than povidone. Copovidone is also used in cosmetics as a thickener, dispersant, lubricant, film-forming agent and binder. It is widely used in the food, cosmetic and pharmaceutical industry.

Is Tablet Binder Copovidone CAS 25086-89-9 the Same as Crospovidone?

Tablet Binder Copovidone CAS 25086-89-9 and crospovidone are commonly used excipients in solid oral dosage forms for many decades. Typically, Copovidonee is used as dry binder and crospovidone as disintegrant in tableting formulations. The use of dry binder and disintegrant needs to be balanced to assure both: strong but quickly disintegrating tablets.

The influence of different Copovidonee and crospovidone grades on the tablet's tensile strength and the ejected solid fraction (or relative density) at different compression pressures were evaluated systematically: Compactability plots (tensile strength as a function of the compression pressure), compressibility plots (ejected solid fraction as a function of the compression pressure) and bondability plots (tensile strength as a function of the ejected solid fraction) were generated to visualize the influence of the individual excipient on the tableting characteristics.

Contour plots were generated to illustrate the influence of each excipient on the tensile strength and disintegration time of the resulting tablets at different compression pressures. Potential interactions and synergies respectively between the different grades of the tested excipients were illustrated.

What Is the Glass Transition Temperature of Tablet Binder Copovidone CAS 25086-89-9?

Both the 10% TPGS, 300 rpm chilled roll and air-cooled samples exhibit an endothermic event with onset of approximately 25°C and maximum of 33°C consistent with melting of TPGS, although pure TPGS melts with an onset of 36°C and maximum of 38°C; thus, some melting point depression has occurred.

The enthalpy of the 10% TPGS, 300 rpm air-cooled endotherm was approximately 0.6 J/g, whereas the chilled roll sample was found to be 0.3 J/g. The 10% TPGS, 600 rpm sample did not exhibit a melting endotherm nor did any of the 5% TPGS or neat Copovidonee samples. For the 10% TPGS samples, a single glass transition was observed in all of the samples at approximately 80–81°C. For the 5% TPGS samples, a single glass transition was observed at 91–92°C, and for the neat Copovidonee samples, the glass transition ranged from 107 to 110°C.

What Is the Role of Tablet Binder Copovidone CAS 25086-89-9 in Tablet Formulation?

Povidone is water soluble, with the maximum concentration being limited only by the solution viscosity. Being nonionic, the viscosity of povidone in an aqueous solution is unaffected by the pH or salt concentration. Povidone is widely used in solid-dosage forms.

In tablet formulations, povidone solution is used as wet-granulation binder. Povidone can also be incorporated to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions. Povidone may be used as a dissolution-enhancing agent in oral formulations for poorly soluble drugs involving processes such as spray drying and hot-melt extrusion.79,89 Povidone is a well-known complexing agent; for example, the ability to complex with iodine is of particular commercial importance, providing an antibacterial povidone iodine solution and powder that are widely used in medical and hospital settings.

Povidone solutions may also be used as a film former for coating formulations or as binders for drug layering onto a substrate such as sugar or microcrystalline cellulose beads. Povidone is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of oral suspensions and solutions. Increasingly due to its advantageous solubility in PEG 400 and glycerin, povidone is also used as a viscosifying and stabilizing agent in liquid-filled gelatin capsules.

Is Tablet Binder Copovidone CAS 25086-89-9 Safe to Ingest?

Large ingestions of povidone are expected to cause only minimal symptoms such as diarrhea. If povidone gets into the eyes or onto the skin, it might cause irritation and pain. There have been reports of severe allergic reactions occurring in sensitive people, but this reaction is rare. Symptoms of a severe allergic reaction include wheezing; difficulty breathing; dizziness; chest tightness; hives; and swelling of the lips, face, tongue, or throat.

Because of povidone's chemical properties, it can reduce the irritating or toxic nature of other drugs when formulated as a combination product.

Povidone is often combined with iodine for use as an antiseptic agent. This combination product is commercially available as the skin antiseptic, but is also available in less concentrated forms for use in the eyes and vagina. In hospital settings, povidone iodine is often used as an antiseptic agent in surgical procedures.

What Are Warnings and Precautions for Tablet Binder Copovidone CAS 25086-89-9?

①Contraindications
· Hypersensitivity

②Effects of drug abuse
· None

③Cautions
· Do not apply over large areas of the body; toxicity may occur if applied in large areas or prolonged periods.
· Not for use in the eyes.
· Use caution in patients with burns
· Ask a doctor in cases of deep or puncture wounds, serious burns, or animal bites.
· Use caution in renal impairment or thyroid disorders.
· Use with caution in children.
· N/t for application to deep puncture wounds or serious burns.
· Discontinue if swelling, redness, pain, or irritation develop, or if the condition persists or gets worse.
· Do not use it for longer than 1 week.
· Keep out of reach of children, if swallowed, get medical help or contact the poison control center right away.
· Pregnancy and Lactation.

Our Factory

The company has the GMP production lines of 600 tons annually of Povidone at low molecular weight ( Povidone K12, K15, K17, K25 and K30), 800 tons annually of Povidone at high molecular weight ( Povidone K60, K90, K120), 300 tons annually of Povidone Iodinated with high stability and 100tons annually of Chondroitine Sulfated Sodium. The company also first finished the industrial cultivation of artificial cultivating of Cordyceps and the concerned products are under marketing now. HSP will take pharmaceutical biological products or biological extracts with advantage of techniques or resources as the new development direction

FAQ

Q: What is the function of tablet binder Copovidonee CAS 25086-89-9?

A: Copovidone, an analog of povidone, is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.

Q: What is the composition of tablet binder Copovidonee CAS 25086-89-9?

A: Copovidone, which is also known as Vinylpyrrolidone-vinyl acetate or Copolyvidone, is acetic acid ethenyl ester polymer with 1-etheny1-2 pyrrolidinone. It is a synthetic random copolymer of 1-vinyl-2-pyrrolidone and vinyl acetate in a ratio (by weight) of 6:3.

Q: Is tablet binder Copovidonee CAS 25086-89-9 the same as crospovidone?

A: Copovidone and crospovidone are commonly used excipients in solid oral dosage forms for many decades. Typically, Copovidonee is used as dry binder and crospovidone as disintegrant in tableting formulations. The use of dry binder and disintegrant needs to be balanced to assure both: strong but quickly disintegrating tablets.

Q: What does tablet binder Copovidonee CAS 25086-89-9 do to the body?

A: Crospovidone is a water insoluble synthetic cross-linked PVP. Crospovidone acts via different mechanisms including the swelling, and wicking followed by secondary swelling as proposed by Kornblum & Stoopak.

Q: What is tablet binder Copovidonee CAS 25086-89-9 derived?

A: Copovidone is manufactured by free-radical polymerization of 6 parts of vinyl- pyrrolidone and 4 parts of vinyl acetate in 2-propanol according to the cGMP reg- ulations. A water-soluble copolymer with a chain structure is obtained.

Q: Is tablet binder Copovidonee CAS 25086-89-9 a binder?

A: Crospovidone is an insoluble form of polyvinylpyrrolidone, and its use in the pharmaceutical industry as a tablet excipient (a tablet disintegrant and binder) has been widely documented. It is medically used for the treatment of some intestinal disorders as solubilizing excipients to improve the bioavailability of drugs (such as steroids) and as germicides in wound treatment.

Q: Why is tablet binder Copovidonee CAS 25086-89-9 used in tablets?

A: Tablet binder Copovidonee CAS 25086-89-9 is a white, free-flowing, water-insoluble superdisintegrant used in tablet formulations to help with disintegration. It can also enhance the solubility of poorly soluble drugs by enabling faster drug dissolution rates through a specific process involving adsorption and evaporation.

Q: What is the tablet binder Copovidonee CAS 25086-89-9 used in tablet?

A: It provides mechanical strength to the tablet. Binders can be in powder form and liquid form. Example of binders are Powder binders: cellulose, methyl cellulose, polyvinyl pyrrolidine, PEG Solution binders: gelatine, PVP, HPMC, PEG, sucrose, starch.

Q: What is the difference between tablet binder Copovidonee CAS 25086-89-9 and crospovidone?

A: Tablet binder Copovidonee CAS 25086-89-9 is a copolymer consisting of povidone and vinyl acetate, and crospovidone consists of povidone that could interact with vinyl acetate in Copovidonee, increasing the bond between powder particles and tablet hardness.

Q: What is the glass transition temperature of tablet binder Copovidonee CAS 25086-89-9?

A: For the 10% TPGS samples, a single glass transition was observed in all of the samples at approximately 80–81°C. For the 5% TPGS samples, a single glass transition was observed at 91–92°C, and for the neat Copovidonee samples, the glass transition ranged from 107 to 110°C.

Q: How long does it take for tablet binder Copovidonee CAS 25086-89-9 to work?

A: In classical antimicrobial testing, povidone iodine has been shown to kill a variety of bacterial strains known to commonly cause nosocomial infections, including methicillin-resistant Staphylococcus aureus (MRSA) and other antibiotic-resistant strains within 20–30 s of exposure.

Q: Is tablet binder Copovidonee CAS 25086-89-9 safe to ingest?

A: Large ingestions of povidone are expected to cause only minimal symptoms such as diarrhea. If povidone gets into the eyes or onto the skin, it might cause irritation and pain. There have been reports of severe allergic reactions occurring in sensitive people, but this reaction is rare.

Q: What is the role of tablet binder Copovidonee CAS 25086-89-9 in formulation?

A: In tablet formulations, povidone solution is used as wet-granulation binder. Povidone can also be incorporated to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions.

Q: Does the body absorb tablet binder Copovidonee CAS 25086-89-9?

A: Tablet binder Copovidonee CAS 25086-89-9 exhibits longer lasting antiseptic effects than tincture of iodine, due to its slow absorption via soft tissue, making it the choice for longer surgeries. Chlorhexidine is almost twice as effective in preventing infection after surgery with a similar to lower risk of adverse events, and the combination of sodium hypochlorite and hypochlorous acid in very low concentration is significantly superior for wound healing.

Q: Does tablet binder Copovidonee CAS 25086-89-9 get rid of fungus?

A: It has a broad spectrum of antibacterial and antifungal activities. Povidone-iodine ointment can be employed effectively in both the closed and open techniques. Quantitative bacteriological assessments imply that iodine is most efficacious when it is administered every 6 hours.

Q: What precautions should be taken when using tablet binder Copovidonee CAS 25086-89-9?

A: Do not apply over large areas of the body; toxicity may occur if applied in large areas or prolonged periods.
Not for use in the eyes.
Use caution in patients with burns.
Ask a doctor in cases of deep or puncture wounds, serious burns, or animal bites.
Use caution in renal impairment or thyroid disorders.

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Tablet Binder Copovidonee CAS 25086-89-9

Why Choose Us?

What Is the Role of Tablet Binder Copovidone CAS 25086-89-9 in Tablet Formulation?

Is Tablet Binder Copovidone CAS 25086-89-9 Safe to Ingest?

Our Factory

FAQ