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Grade: Food grade product-1-1
Chemical name: Insoluble Polyvinylpyrrolidone
USP/EP name: Crospovidone
Synonyms: Crospovidonum; crosslinked PVP
INCCTFA name: Insoluble PVP
Molecular formula: (C₆H₉NO)n

Use: Used in tablets
CAS NO.25249-54-1
Trade name: Sunvidone CL

Characteristics

White to yellowish fine powder
Hygroscopic
Odorless or with a faint characteristic odor
Insoluble in water, alkali, acid and common organic solvents
Easily swellable in water without forming gels
According to different particle sizes, it is divided into type A and type B.

Specification

Sunlydone		CL	CL-R	CL-S
PH (10% suspension)		5.0-8.0	5.0-8.0	5.0-8.0
Water, % max.		6.0	6.0	6.0
Sulphate ash, % max.		0.4	0.4	0.4
Water-soluble substances, % max.		1.0	1.0	1.0
Free-NVP, mg/kg max.		10	10	10
Free-N,N'-Divinylinidazolidone, mg/kg max.		2	2	2
Lead, mg/kg max.		5	5	5
Nitrogen, %		11.0-12.8	11.0-12.8	11.0-12.8
Particle size, microns		0-300	45%<75	100%<75
Particle size, microns		0-300	15%<37
Equivalent to	BASF's		Divergan R	Divergan F
	ISP's	Disintex	Polgclar R	Polyclar 10/V

Application

Super Disintegrant
Crospovidone acts as an excellent super disintegrant for tablets and capsules. It absorbs water quickly and swells remarkably, enabling rapid tablet disintegration and fast drug dissolution.

Tablet Quality Improver
Enhances tablet hardness and reduces friability, effectively preventing tablet cracking, chipping and breakage during pressing, packaging and transportation.

Formula Compatibility
Features excellent chemical stability and wide compatibility with most API and excipients. No adverse reaction with drug ingredients, ensures long-term formulation stability.

Wide Pharmaceutical Application
Suitable for immediate-release tablets, chewable tablets, effervescent tablets and hard capsule formulations, widely applied in generic drugs, health care products and functional solid preparations.

FAQ

1.How does PVPP affect drug release in tablets?
By combining with drugs, the release rate of drugs can be adjusted, especially in sustained-release or controlled-release tablets. By adjusting the cross-linking degree of PVP, the release rate of drugs in the body can be controlled.

2. Does PVPP affect the absorption of drugs?
In most cases, there is no negative effect on the absorption of drugs. It can also help some poorly soluble drugs to dissolve better, thereby improving the bioavailability of drugs.

3. How safe is PVP in tablets?
Its use in the pharmaceutical industry has been certified by many pharmacopoeias such as the FDA and the European Pharmacopoeia. It has no toxic side effects and is well tolerated by the human body.

4. How does PVPP help improve the stability of tablets?
It has good biocompatibility and chemical stability, and can effectively prevent drug ingredients from being affected by external environmental factors such as moisture and oxygen.

5. Is PVPP suitable for all types of drug tablets?
It is suitable for most types of tablets, especially oral tablets, sustained-release tablets and controlled-release tablets.

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Polyvinylpyrrolidone Used in Tablets