Professional Manufacturer of Crospovidone Series Stabilizer for Suspension

Hangzhou Rainbow Import & Export Co., Ltd. is a reliable supplier of professional manufacturer of crospovidone series stabilizer for suspension in China, providing professional sales and export services to global customers. As a sales partner of Huzhou Sunflower Pharmaceutical Co., Ltd., an experienced manufacturer of professional manufacturer of crospovidone series stabilizer for suspension, we connect buyers with qualified manufacturers and suppliers and support customized product requirements. Our manufacturing partner's factory provides production support for customer orders. For product specifications, customized solutions, or free sample inquiries, please feel free to contact us.

Synonyms: Crospovidone;Crospovidonum;                

Insoluble polyvinylpyrrolidone, crosslinked PVP

INCI: PVPP

CAS No.:[9003-39-8]

Trade Name: Sunvidone^® CL

SPECIFICATION

CRACTERISTICS

SUNVIDONE® CL series are supplied as fine white or almost white powders. They have a slight characteristic odour and are practically tasteless. They are insoluble in all the usual solvents.

APPLIICATIONS

SUNVIDONE® CL series possess a number of useful properties for pharmaceutical products.

- Improvement of tablet disintegration and therefore also of release and bioavailability of drugs through predictable swelling (disintegration effect)

- Improvement of release and bioavailability of drugs through complexation.

- Selective adsorption of polyphenols by complexation

- Stabilization of suspensions by Sunvidone® CL, as a hydrophilic polymer

- Complexation of endotoxins

- Adsorption of water

PACKAGES                       

20KG or 25KG net in fiber drum or PP drum

Frequently asked question

What are the differences between polyvinylpolypyrrolidone (PVPP) and polyvinylpyrrolidone (PVP)?

Polyvinylpolypyrrolidone (polyvinyl polypyrrolidone, PVPP, crospovidone, crospolividone or E1202) is a highly cross-linkedmodification of polyvinylpyrrolidone (PVP). The cross-linked form of PVP is used as a disintegrant (see also excipients) in pharmaceutical tablets. PVPP is a highly cross-linked version of PVP, making it insoluble in water, though it still absorbs water and swells very rapidly generating a swelling force. This property makes it useful as a disintegrant in tablets. It is also used as a fining to extract impurities (via agglomeration followed by filtration). It is used in winemaking. Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced. One such commercial product is called Polyclar. PVPP forms bonds similar to peptidic bonds in protein (especially, like proline residues) and that is why it can precipitate tannins the same way as proteins do.

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.

As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine or some beers. It is used as a binder in many pharmaceutical tablets. PVP is also used in many technical applications.

More than 30 years ago insoluble PVP was used to adsorb poluphenols. In addition, PVP is used to help extracting polyphenols via its capability to hydrogen bond with these entities.

The role of PVP in the process of DNA extraction from plants is to help to remove all phenolic derivatives in order to get high uality DNA.

The buffers used in the case of PVP are:

Buffer 1: 200 mM Tris–HCl, 1.4 M NaCl, 0.5 % (v/v) Triton X-100, 3 % (w/v) CTAB, 0.1 % (w/v) PVP (add to buffer only before use).

Buffer 2: 50 mM Tris–HCl, 2 M guanidinethiocyanate, 0.2 % (v/v) mercaptoethanol (add to buffer only before use), 0.2 mg/ml Proteinase K (add to buffer only before use).

For more information on this topic, please see the recent publication entitled "An efficient protocol for isolation of inhibitor-free nucleic acids even from recalcitrant plants "  published in 3 Biotech. 2016 Dec;

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