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CAS Number: [25086-89-9]
Synonym: Copovidone
CTFA/INCI: VP/VA Copolymer
Description: Copolymerized polyvinylpyrrolidone (PVP) and vinyl acetate (VA)
Origin: Zhejiang, China
Powder: Yes
As a synergist, copovidone has become an important excipient in various industries due to its superior bonding, film-forming and controlled-release properties.

Characteristics

White powder or granules.
Soluble in water and a variety of organic solvents, making it suitable for different types of formulations and helping active ingredients dissolve and absorb better.
Gentle and non-irritating to the skin and mucous membranes, suitable for sensitive skin.
Strong adhesive properties, can enhance the bonding force between particles and improve the compressibility and strength of solid preparations (such as tablets).

Specification

Meets the requirements of the latest USP/NF, Ph.Eur. and JPE
Appearance of solution (10%)	BY5, B5min.	Heavy metals	20ppm max
Aldehydes	500ppm max.	Loss on drying	5.0% max
Peroxides	400ppm max.	sulphated ash	0.1% max
Hydrazine	1ppm max.	K value	25.2-30.8
Monomers	0.1% max.	Ethenyl acetate	35.3%-42.0%
Impurity A	0.5% max.	Nitrogen	7.0%-8.0%

Application

Pharmaceutical field: It is often used in solid preparations such as tablets, capsules, and film coatings as a binder, disintegrant, and controlled-release material.
Cosmetics: In skin care and hair care products, it acts as a film former and moisturizer to improve the texture and stability of the product while helping the absorption of active ingredients.
Food industry: Copovidone is also used as a food enhancer to improve the texture and stability of food, especially in soft candies and jelly-like foods.

FAQ

1.Why is copovidone used in pharmaceutical preparations?

In pharmaceutical preparations, it can improve the adhesion, formability and release control of drugs, help achieve sustained and controlled release effects, and improve the bioavailability of drugs.

2. How does copovidone improve drug absorption?

It can help active ingredients enter the body more quickly and effectively by enhancing the solubility and absorption rate of drugs, thereby improving the absorption rate of drugs.

3. What is the role of copovidone in cosmetics?

It is used as a film former, humectant and stabilizer to help cosmetics form a uniform protective film, improve texture and moisturizing effect.

4. Is copovidone suitable for people with sensitive skin?

It has good biocompatibility and is mild and non-irritating to the skin and mucous membranes, so it is suitable for most skin types, including sensitive skin.

5. How does copovidone affect the texture of food?

In the food industry, copovidone can improve the texture of food, making it softer and more elastic, especially in soft candies and jelly foods.

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