This product is a water-soluble synthetic polymer compound, a linear homopolymer of N-vinylpyrrolidone, with a molecular formula of (C₆H₉NO)n, where n represents the average number of N-vinylpyrrolidone chains. The most commonly used excipient is povidone K30, with an average viscosity-average molecular weight of 3.8×104; followed by povidone K15, K25, and K90, with average viscosity-average molecular weights of 0.77×104, 2.5×104, and 63×104, respectively.

Poly(N-Vinyl Pyrrolidone) Standards

Shenghui	K15	K17	K25	K30	K90
Solution appearance (5% aqueous solution) min.	BY₆	BY₆	BY₆	BY₆	BY₆
Formic acid, % max.	0.5	0.5	0.5	0.5	0.5
Peroxide, ppm max.	400	400	400	400	400
K value	12.8-17.3	15.3-18.4	22.5-27.0	27.0-32.0	81.0-97.2
Aldehyde, % max.	500	500	500	500	500
Residual monomer, ppm max.	10	10	10	10	10

Product features Poly(N-Vinyl Pyrrolidone)

This product is a white to milky white amorphous powder, odorless or slightly odorless; tasteless; hygroscopic, soluble in water, ethanol, isopropyl alcohol, glycerin or chloroform, insoluble in acetone, ether and hydrocarbon solvents.

●This product can complex with many substances, especially compounds containing active hydrogen atoms or metal carbonyl compounds, to form solid complexes, which can improve the properties of the complexed substances such as solubility, volatility, stability, toxicity and irritation. Wait for significant but reversible changes to occur. When applying excipients, many dosage forms with new functions can be developed or the performance of original dosage forms can be improved.

●This product is stable under normal conditions and has strong tolerance to heat, acid and alkali.

Poly(N-Vinyl Pyrrolidone) application

Shenghui K series products can be used as binders for granules and tablets, and as thickeners and suspending agents for liquid preparations. Co-solvents and stabilizers for preparations, film-forming agents and pigment dispersants for coatings, coprecipitants for poorly soluble drugs, extenders and lubricants for eye drops, and sustained-release agents for controlled-release dosage forms, etc.
The function of PVP in preparations is closely related to its molecular weight, dosage, solvent, solution concentration, temperature, processing technology, etc. Therefore, to obtain better preparation performance, you must first be familiar with the physical and chemical properties of PVP, and start from the target function to be achieved by the prescription. , choose the optimal molecular weight, dosage, solvent, compatibility, and process.

Poly(N-Vinyl Pyrrolidone) packaging

25KG fiberboard drum, full paper square drum or PP drum

FAQ

Q: What are the unique characteristics and advantages of Poly (N-Vinyl Pyrrolidone) compared to other similar polymers?

A: The polyvidone we supply has excellent solubility. It can dissolve quickly and completely in a variety of solvents, including water and some common organic solvents, which makes it highly flexible in the formulation design of pharmaceutical preparations. At the same time, it has good film-forming properties. The film formed is tough and has a certain degree of flexibility, which can effectively protect the active ingredients of the drug and control its release rate. In addition, polyvidone has high chemical stability. Under normal storage and use conditions, it can maintain the stability of its structure and performance, and is not prone to degradation or chemical reactions, thereby ensuring the long-term reliability of the quality and efficacy of the drug.

Q: If we encounter problems in the application of polyvidone in the development of new pharmaceutical preparations, what technical support can you provide?

A: We have a professional technical team who have rich experience and deep expertise in the application of polyvidone. If you encounter problems during the formulation development process, we can provide you with formulation design suggestions, and help you determine the optimal concentration of povidone, molecular weight range, and compatibility with other excipients based on your drug active ingredients and formulation goals. We can also provide optimization guidance on process parameters such as povidone dissolution, drying, and film formation, helping you solve technical problems that may arise in the actual production process, ensuring that your drug formulation development project can be smoothly promoted and ultimately successfully launched on the market.

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