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Chemical Name:Vinylpyrrolidone/Vinylacetate copolymers
USP/EP Name:Copovidone
INC/CTFA Name:VP/VA COPOLYMER
Molecular Formula:(C₆H₉NO)n·(C₄H₆O₂)m
CAS No.25086-89-9
It is a vinylpyrolidone-vinyl acetate copolymer that is soluble both in water and inalcohols.
It is used in the pharmaceutical industry as binders,granulating agents,retarding agents and film forming agents in drugs.

Characteristics

White or slightly yellowish, non-flowing powder, with a weak characteristic odor, almost tasteless.

Easily soluble in all hydrophilic solvents. Solutions with concentrations exceeding 10% can be prepared in water, ethanol, isopropanol, dichloromethane, glycerol, propylene glycol, and have low solubility in ether, cycloaliphatic and alicyclic hydrocarbons.

Specification

Appearance of solution(10%)	BY₅,B₅min.	Impurity C	10ppm max.
K value	25.2-30.8	Heavy metals	20ppm max
Aldehydes	500ppm max.	Loss on drying	5.0%max
Peroxides	400ppm max.	sulphated ash	0.1%max
Hydrazine	lppm max.	Ethenyl acetate	35.3%-42.0%
Impurity A	0.5%max.	Nitrogen	7.0%-8.0%
Impurity B	10ppm max.

Application

•Binder for tablets and granules	Sunvidone® VA is an excellent binder for tablets and granules.
•Dry binder for direct compression	Between 2% and 5%, as a proportion of the final weight of the
•Wet granulation	Preparation, is usually used.
• Film-coating	Sunvidone® VA forms films that are soluble at all pH values.
• Subcoating	Sunvidone® VA is used in sugar-coating to improve the
• Sugar-coating	Adhesion of the coating to the surface of the tablet core and to
• Sprays	Increase the capacity of the coating solution for pigments and
• Controlled-release preparations	Improve their dispersibility.

FAQ

1.What are the advantages of Copovidone?

Excellent biocompatibility, suitable for human drugs.
Wide applicability, suitable for various types of preparations (such as tablets, granules, capsules, liquid preparations).
Highly efficient bonding ability, ensuring the stability and uniformity of tablets.

2. What preparations is Copovidone suitable for?
It is suitable for a variety of preparations, including pharmaceutical tablets, granules, capsules and liquid preparations, and is a commonly used excipient in drug development.

3. What precautions should be taken when using Copovidone?
Attention should be paid to its dosage, compatibility and potential side effects. Relevant regulations and standards should be followed during the production process to ensure the safety and effectiveness of the final product.

4. Does Copovidone affect the release characteristics of the drug?
Copovidone can adjust the release rate of the drug, so it can effectively improve the efficacy of the drug in sustained-release and controlled-release preparations.

5. How to store Copovidone?
It should be stored in a cool, dry place, avoiding moisture and high temperature to maintain its performance and shelf life.

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