Hangzhou Rainbow Import & Export Co., Ltd. is one of the leading manufacturers and suppliers of nvp crosslinked polymers for tablet binders in China. With abundant experience, we warmly welcome you to buy customized nvp crosslinked polymers for tablet binders from our factory. If you have any enquiry about free sample, please feel free to email us.

NVP cross-linked polymer (N-vinylpyrrolidone cross-linked polymer) is a type of polymer material that uses N-vinylpyrrolidone (NVP) as a monomer and forms a three-dimensional network structure through a cross-linking reaction. In tablet preparations, it is often used as a superdisintegrant for rapid tablet disintegration. With its unique chemical structure and physical properties, it plays an important role in improving tablet formability, stability and drug release performance.

Product Features

●Insoluble but highly swellable: Due to the cross-linked structure, the polymer is insoluble in water or organic solvents, but when in contact with water or polar solvents, it will quickly absorb liquid and swell (the volume can expand several times), forming a viscous gel network.
●Chemical stability: The molecular structure does not contain easily hydrolyzed or oxidized groups, has strong tolerance to acid, alkali, temperature, and humidity, and has good compatibility with most drugs and excipients (such as fillers and lubricants).
●Adjustability: By changing the degree of cross-linking (amount of cross-linking agent), its swelling rate, viscosity and mechanical strength can be adjusted to meet the needs of different formulations.

Product core parameters

Parameter Category	Specific Indicator	Typical Value/Range	Reference Test Method
Chemical Composition	Residual NVP Monomer Content	≤0.1%	GC (Gas Chromatography)
	Crosslinking Agent Content	1.0 - 3.0% (based on total monomer mass)	Titration Method
Physical Properties	Average Particle Size (D50)	80 - 150 μm	Laser Particle Sizer
	Specific Surface Area	50 - 100 m²/g	BET Adsorption Method
	Liquid Absorption Capacity (Deionized Water)	20 - 50 g/g	Centrifugal Separation Method
Rheological Properties	Viscosity of 1% Aqueous Solution (25°C, 10rpm)	5000 - 15000 mPa·s	Rotational Viscometer (Brookfield LVDV)
	Thixotropic Index (3rpm/30rpm)	2.0 - 4.0	Same as viscosity test conditions
Stability	Thermal Weight Loss Temperature (5% weight loss)	≥200°C	TGA (Thermogravimetric Analysis)
	UV Resistance (254nm, 24h)	Viscosity Retention Rate ≥90%	Accelerated Aging Test
Safety Indicators	Total Heavy Metals	≤10ppm	ICP-MS
	Microbial Limit	Bacteria ≤100CFU/g, Mold ≤10CFU/g	Plate Count Method

Mechanism of action as a tablet binder

The core function of tablet binders is to bind drug powders, fillers, disintegrants and other materials together to form particles with a certain hardness and integrity (granulation stage), and finally press them into qualified tablets. The bonding mechanism of NVP cross-linked polymers is mainly based on the following two points:

●Swelling produces viscosity: In wet granulation, when the polymer is mixed with the material and a solvent (such as water, ethanol) is added, the polymer particles swell rapidly, and a sticky gel layer is formed on the surface. The adjacent powder particles are "bonded" through intermolecular forces (such as hydrogen bonds and van der Waals forces) to form solid wet particles.

●Mechanical anchoring of three-dimensional network: The mesh structure formed by cross-linking still maintains a certain rigidity after drying, and can tightly bind the particles through mechanical anchoring to avoid problems such as cracking and loose tablets during tableting, ensuring that the tablet hardness meets the standard.

Applicable Product Types

●Rapid-release preparations: drugs that require rapid tablet disintegration (such as antipyretic analgesics), the property of bonding that does not hinder disintegration can ensure rapid drug release.
●Poorly soluble drug tablets: by improving the binding force between particles, while using swelling to promote drug dissolution and improve bioavailability.
●Tablets with high hardness requirements: such as chewable tablets and lozenges, require higher hardness to avoid breakage, and their cross-linked structure can provide stable mechanical strength.
●Moisture-sensitive drugs: such as certain antibiotics and vitamins, can reduce stability problems caused by moisture absorption.

Hangzhou Rainbow Import & Export Co.,Ltd

In 1992, Zhejiang Sunflower New Material Co., Ltd., the predecessor of the company, was established, specializing in PVP production. Mr. Wu Jiaxiang, the chief expert of the national PVP R&D project, served as the general manager. In 2002, the company was restructured into a private enterprise and established Hangzhou Sunflower Technology Development Co., LTd. (STD), continuing to engage in the R&D and production of PVP series APIs and cosmetic-grade products.

Professional team

Mr. Wu Jiaxiang, the chief expert of the national PVP R&D project, served as the general manager;PVP's main founder, professor-level senior engineer Wu Jiaxiang, led the

Business philosophy

"Innovation as the source, service as the basis"

Hangzhou Rainbow Import & Export Co.,Ltd

1992

Establish

35 Years

Experience

600 Tons

Low Molecular Weight Povidone

800 Tons

High Molecular Weight Povidone

FAQ

What are the chemical structural characteristics of NVP cross-linked polymers and their advantages as adhesives? 
It is made of cross-linked NVP monomers and contains pyrrolidone rings and three-dimensional network structures. Polar groups enhance adhesion, and cross-linked structures enhance mechanical strength. It is suitable for high-hardness tablets and is superior to linear PVP.

pH stability and applicable formulation types? 
Stable at pH 1.0-8.0, with a 72-hour change in key indicators of less than 3%. It can be used for acidic and weakly alkaline formulations without affecting the adhesive properties.

Does it react with drugs containing aldehyde or amino groups? 
It does not contain active groups, does not undergo Schiff base or amidation reactions, and the accelerated test shows that the drug content decreases by less than 2%, indicating good compatibility.

Biocompatibility and in vivo metabolism? 
It is non-toxic (LD50>10g/kg), not absorbed by the gastrointestinal tract, and excreted with feces, meeting the USP-NF oral excipient safety requirements.

What is the range of cross-linking degree and its effect on disintegration?
The cross-linking degree is stable at 85%-92%, ensuring the tablet hardness without affecting disintegration. The disintegration time is 5-15 minutes, which meets the pharmacopoeia standards.

Particle size distribution and its impact on granulation?
The particle size is 50-150μm (D50 is about 80μm), evenly distributed, which can improve the granulation mixing uniformity and adapt to a variety of granulation processes.

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