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Model NO.: 25086-89-9
Suitable for: Elderly, Adult
Function: Tablet Binder
Certification: ISO 9001
Molecular Formula: C30h45n3o9X2
Origin: Made in China
Tablet Binder Copovidone CAS 25086-89-9
1. Quick Detail:
|Other Name:||Poly(1-vinylpyrrolidone-co-vinyl acetate); Aceticacid,ethenylester,polymerwith1-ethenyl-2-pyrrolidinone;aceticacidethenylester,polymerwith1-ethenyl-2-pyrrolidinone;aceticacidethenylestercopolymerwith1-ethenyl-2-pyrrolidinone;aceticacidvinylester,polymerwith1-vinyl-2-pyrrolidinone;copolyresinvinylketopyrrolidine/vinylacetate;copolyvidon;e335;e535|
|Leading time||within 24 hours upon receipt of payment|
|Package||Discreet and Hidden package according to specific requirement|
|Usage||Copovidone, an analog of povidone, is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations.|
The Copovidone is a water-soluble organic polymer, and is a linear copolymer of vinyl N- (NVP) and vinyl acetate (VA). (PVP/VA)
Nature:Since the structure of and NVP is the structure of and VA, it has the properties of both PVP and PVAC. Compared the nature of the above three products, polyvidone retained the good PVP water solubility, adhesion and membrane, and than the PVP is relatively much lower water absorption and more broad solubility, better plasticity and stronger surface activity (Note: the vegetables on the surface of the water affinity than PVP).
Therefore, this product is a kind of fine tablet binder, which has the characteristics of high hardness and low brittleness, and can be used in the wet conditions. It is especially suitable for high dose, poor water solubility and water sensitive drug.
1. Copovidone, an analog of povidone, is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
2. Copovidone has better plasticity than povidone as a tablet binder, is less hygroscopic, more elastic, and better for film-forming applications than povidone. Copovidone is also used in cosmetics as a thickener, dispersant, lubricant, film-forming agent and binder. It is widely used in the food, cosmetic and pharmaceutical industry.
3. Copovidone is generally regarded as nontoxic. However, oral consumption of excessive quantities may produce stomach upset. It has not been shown to be sensitizing to the skin. Animal studies in rats and dogs do not show significant toxicity with high dietary levels.
4. As tablet and granule, the adhesive can be used wet, dry granulation and direct compression method to complete, in most cases the dosage of micro gross preparation of 2% - 5%, general is about 3%, concentration of adhesive generally 5 ~ 10%. According to the different materials and auxiliary materials, water or alcohol and other solvents can be used as solvent.
When the direct compression method is used, the dosage is about 5%, which can be used as the auxiliary material, such as lactose, sorbitol, mannitol and microcrystalline cellulose, but it should pay attention to controlling the moisture content in the ingredients to maintain proper bonding.
1.Water soluble tablet binder:suitable wet or dry granulation and direct compression processes,improves particle compressibility.
2.Film-former:permeable film coating for tablet and sugar coatings to protect against splitting,decrease moisture sensitivity and provide good film adhesiveness,elasticity and hardness.
3.Porogenic agent:for use in taste-masking and component of the matrix material used in controlled-release formulation.
4.Solubilizing agents:for solid depersion processes to enhancing bioavailability and improve drug solubility.
5. Technical Testing Sheet
|PH value (1% in water)||5.0-7.0||5.6|
|Monomer (VP+VA) ppm||≤ 10||<10|
|Heavy metal (as lead) %||≤ 0.001||< 0.001|
|Aldehyde ppm||≤ 500||< 500|
|NVP %||≤ 0.20||0.09|
|Moisture %||≤ 5.0||3.62|